To become detached.
One of the wagon wheels came off.
To have some success; to succeed.
He tried his Chaplin impression, but it didn't really come off.
To have an orgasm.
To appear; to seem; to project a certain quality.
I'm sorry if I came off as condescending; that wasn't my intention.
To escape or get off (lightly, etc.); to come out of a situation without significant harm.
To come away (from a place); to leave.